Race Specificity of disease resistance QTL

Saw line-specific as well as line-non-specific response.

Do these dichotomies really exist?

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Do these dichotomies really exist?

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Do these dichotomies really exist?

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Do these dichotomies really exist?

Quantitative resistance is, by definition, partial

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Lots of examples of this type of thing

“Ghost” effects

So are Quantitative resistance genes similar to major R-genes?

Perhaps R-genes products that interact weakly with their corresponding Avr genes products/ guardee proteins cause partial resistance?

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R-genes can’t be the whole story surely!

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Cloned Quantitative Disease Resistance Genes

Fu et al. 2009. A Kinase-START Gene Confers Temperature-Dependent Resistance to Wheat Stripe Rust. Science 323:1357-1360.

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Krattinger et al. 2009. A Putative ABC Transporter Confers Durable Resistance to Multiple Fungal Pathogens in Wheat. Science 323:1360-1363.

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Manosalva, et al. 2009. A Germin-Like Protein Gene Family Functions as a Complex Quantitative Trait Locus Conferring Broad-Spectrum Disease Resistance in Rice. Plant Physiol. 149:286-296.

Fukuoka et. Al 2009 Loss of Function of a Proline-Containing Protein Confers Durable Disease Resistance in Rice Science 325: 998 - 1001

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What does this tell us?

Is quantitative resistance effective against multiple diseases

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So what use are dQTL?

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The Catch-22 can be avoided if:

In other words…