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North Carolina State University
Center for the Biology of Nematode Parasitism
Suite 1400 Partners Building II
Centennial Campus
Campus Box 7253
Raleigh, NC 27695-7253
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The Center for the Biology of Nematode Parasitism exploits opportunities in post-genomic biology.

This Center integrates knowledge and research of free-living and parasitic nematodes and exploits model systems to make strides in understanding the basic mechanism of parasitism.


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Results | VOL VII, NO 2 | Summer 2007
Rooting Out Nematodes
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Results | VOL VI, NO 3 | Fall 2006
Mining Gene Data from Golden Leaf
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02.22.2005
Study: Friends, Enemies Communicate With Plants in Similar Ways

12.08.2004
Researchers Receive $1.59M Grant to Map Genome of Parasitic Worm


05.20.2003
New Evidence Suggests Genes in Parasites Were Acquired From Bacteria


Perspectives | Spring 2003
On The Map
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12.11.2002
Philip Morris USA Provides $17.6 Million for Tobacco Genome Mapping


06.24.2002
Researchers Aim to Find New Ways to Protect Against Nematodes


Results | VOL II, NO I | Spring 2000
Eco-Genomics: Researchers Race Clock To Find Safer Nematode Solution
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09.29.2000
NC State Receives $2.6 Million NSF Grant to Study Parasite's Genetics


Perspectives | Spring 1999
The Genomic Fast Track
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Charles H. Opperman

Charles H. Opperman

Professor

  • B. S. Agronomy - Plant Breeding specialization, University of Florida, Gainesville, FL
  • Ph.D. Nematology, University of Florida, Gainesville, FL

Charles Opperman is the Project Director for the Tobacco Genome Initiative, which aims to sequence tag greater than 90% of the genes in Nicotiana.

In addition, his group is completing a whole genome shotgun sequence of the nematode-parasitic bacterium, Pasteuria penetrans.

Opperman is also the Project Director to sequence the genome of the plant parasitic nematode, Meloidogyne hapla (root-knot nematode).

Research in his laboratory focuses on several major areas. The main thrust of the program is aimed at understanding the cellular and genetic basis of parasitism. A key approach in all of these projects is using phylogenetic relationships to help determine gene function and evolution.

In addition, he is keenly interested in the differences between free-living and parasitic nematode species. For example, the root-knot nematode sequencing project will take advantage of genome co-linearity with Caenorhabditis elegans. Similar approaches have been utilized for the bacterial sequences and the solanaceous tobacco genes.

Professional Experience

1985 - 1987 Senior Research Nematologist, Biological Research Group Union Carbide Agricultural Products Co.
1987 - 1993 Assistant Professor, Department of Plant Pathology, NCSU
1993 - 1998 Director, Molecular Crop Protection Training Program, NCSU
1993 - 2000 Associate Professor, Departments of Plant Pathology and Genetics, NCSU
1993 - present Biotechnology Faculty member, NCSU
1998 - 2002 Executive Director, Genome Research Laboratory, NCSU
1998 - present Lawes Trust Senior Fellow,Rothamsted Experiment Station, UK
1999 - present Genomic Sciences Faculty member, NCSU
1999 - present Director, Center for the Biology of Nematode Parasitism, NCSU
2000 - present Professor, Departments of Plant Pathology and Genetics, NCSU

Publications

Dhandaydham, M., Charles, L.,Zhu, H., Starr, J.L., Huguet, T., Cook, D.R., Properi, J-M. Bird, D.M., and Opperman, C.H. 2005. Identification, characterization and mapping of a root-knot nematode resistance gene in Medicago truncatula. Molecular Plant Microbe Interactions, accepted after revisions.

Kojetin, D., Thompson, R., Benson, L., Naylor, S., Waterman, J., Davies, K., Opperman, C., Stephenson, K., Hoch, J., and Cavanagh, J. 2005. Structural analysis of metal binding to the Bacillus subtilis response regulator Spo0F: a possible role for metalloregulation in the initiation of sporulation. In press: BioMetals.

Charles, L., Carbone, I., Davies, K., Burke, M., Kerry, B., Bird, D., and Opperman, C.H. 2005. A phylogenetic analysis of Pasteuria penetrans using multiple genetic loci. Journal of Bacteriology 187:5700-5708.

Dong, K., Barker, K. R., and Opperman, C. H. 2005. Virulence Genes in Heterodera glycines: Allele Frequencies and Ror Gene Groups Among Field Isolates and Inbred Lines. Phytopathology 95:186-191.

Bird, D. McK., Opperman, C. H. and K. G. Davies. 2003. Interactions between bacteria and plant-parasitic nematodes: Now and then. International Journal of Parasitology 33: 1269-1276.

Koltai, H., Dhandaydham,M., Opperman, C. H., Thomas J. and D. McK. Bird. 2001. Overlapping plant signal transduction pathways induced by a parasitic-nematode and a rhizobial endosymbiont. Molecular-Plant Microbe Interactions 14,1168-1177.

Kaplan, D.T., and Opperman, C.H. 2000. Reproduction strategies and karyotype of the burrowing nematode, Radopholus similis. Journal of Nematology. 32, 126-133.

Kaplan, D.T., Thomas, W.K., Frisse, L., Sarah, J.L., Stanton, J.M., Speijer, P.R., Marin, D.H., and Opperman, C.H. 2000. Phylogenetic analysis of geographically diverse Radopholus similis via rDNA sequence reveals a monomorphic motif. Journal of Nematology 32, 134-142.

Marin, D.H., Barker, K.R., Kaplan, D.T., Sutton, T.B., and Opperman, C.H. 2000. Development and evaluation of a standard method for screening for resistance to Radopholus similis in bananas. Plant Disease 84, 689-693.

Marin, D.H., Barker, K.R., Kaplan, D.T., Sutton, T.B., and Opperman, C.H. 1999. Aggressiveness and damage potential of Radopholus spp. from Central America and the Carribean. Journal of Nematology 31,377-385.

Marin, D.H., Sutton, T.B., Barker, K.R., Kaplan, D.T., and Opperman, C.H. 1999. Burrowing-nematode resistance of black-sigatoka resistant banana hybrids. Nematropica 28,241-247.

Marin, D. H. , Kaplan, D. T., and Opperman, C.H.. 1999. RAPD analysis discerns collection site of burrowing nematode isolates but not their host range or reproductive potential on banana or citrus. Journal of Nematology 31,232-239.

Opperman, C.H., and Bird, D.McK. 1998. The soybean cyst nematode, Heterodera glycines: a genetic model system for the study of plant-parasitic nematodes. Current Opinions in Plant Biology 1, 342-346.

Bird, D.McK., and Opperman, C.H. 1998. Caenorhabditis elegans: a genetic guide to parasitic nematode biology. Journal of Nematology 30,299-308.

Kaplan, D.T., and Opperman, C.H. 1997. Genome similarity implies that citrus-parasitic burrowing nematodes do not represent a unique species. Journal of Nematology 29,430-440.

Kaplan, D.T., Vanderspool, M.C., and Opperman, C.H. 1997. Sequence tag site and host range assays demonstrate that Radopholus similis and R. citrophilus are not reproductively isolated. Journal of Nematology 29,421-429

Dong, K., Barker, K.R., and Opperman, C.H. 1997. Genetics of soybean-Heterodera glycines interactions. Journal of Nematology 29,509-522.

Dong, K., and Opperman, C.H. 1997. Genetic analysis of parasitism in Heterodera glycines. Genetics, 146,1311-1318.

Kaplan, D.T., Vanderspool, M.C., Garrett, C., Chang, S., and Opperman, C.H. 1996. Molecular Polymorphisms associated with host range in the highly conserved genomes of the burrowing nematodes, Radopholus spp. Molecular Plant-Microbe Interactions 9, 32-38.

Sherwood, J., Beute, M., Elliot, V., Nelson, R., Opperman, C., Rodriguez-Kabana, R., and Shew, B. 1995. Biological and biotechnological control advances in Arachis diseases. pp. 160-206 in: Advances in Peanut Science.

Pattee, H. E., and Stalker, H. T., eds. Opperman, C. H., and Conkling, M. A. 1994. Nematode-induced plant gene expression and related control strategies. Fundamental and Applied Nematology 17, 211-217.

Opperman, C. H., Taylor, C. G., and Conkling, M. A. 1994. Root-knot nematode directed expression of a plant root-specific gene. Science 263, 221-223.

Book Chapters (past 10 years)

Opperman, C.H. 2002. Mechansims of nematode parasitism: A genetic approach. Pp. 203-207 in Biology of Plant-Microbe Interactions, Volume 3. Leong, S.A., Allen, C., and Triplett, E.W., eds. ISMPMI, St. Paul, MN.

Opperman, C.H. 2001. Forward genetic analysis of plant nematode parasitism. Pp. 45-51 in: Molecular Nematology. Kennedy, M., ed. CABI Publishing, Oxon, UK.

Opperman, C.H., and Bird, D.McK. 2001. Nematode genetics. Pp. 696-697 in: Encyclopedia of Plant Pathology. Maloy, O.C., and Murray, T.D., eds. Wiley and Sons, New York.

Bird, D.McK., Opperman, C.H., Jones, S.J., and Baillie, D. 1999. The Caenorhabditis elegans genome: A guide in the post genomics age. in: Annual Review of Phytopathology 37, 347-365.

Opperman, C.H. 1998. Differential plant-parasitic nematode sensitivity to acetylcholinesterase inhibitors. pp. 521-527 in: Structure and Function of Cholinesterases and Related Proteins.

Doctor, B.P., Quinn, D.M., Rotundo, R.L., and Taylor, P., eds. Opperman, C.H., and Conkling, M.A. 1998. Biotechnological approaches to improved host resistance to nematodes. pp. 239-250 in: Plant-Nematode Interactions.

Barker, K.R., Pederson, G.A., and Windham, G.L., eds. Opperman, C.H., and Conkling, M.A. 1996. Root-knot nematode induced TobRB7 expression and antisense transgenic resistance strategies. pp. 521-526 in: Advances in Molecular Genetics of Plant-Microbe Interactions, Vol. 4.

U.S. Patents

Conkling, M.A., Opperman, C.H., Acedo, G.N., and Song, W. United States Patent #6,008,436. Nematode Resistant Transgenic Plants. Issued 28 December 1999.

Conkling, M.A., Opperman, C.H., and Taylor, C.G. United States Patent #5,750,386. Pathogen Resistant Transgenic Crop Cultivars. Issued, 12 May 1998.

Miscellaneous articles

Opperman, C.H. 1999. Book Review: The Physiology and Biochemistry of Free-Living and Plant Parasitic Nematodes. Perry, R.N., and Wright, D.J., eds. Plant Pathology 48,146.

Opperman, C.H. 1996. Current trends in molecular analysis of nematode-plant interactions. Meeting review of 8th International Congress of Plant-Microbe Interactions. Molecular Plant-Microbe Interactions , December, 1996.

Opperman, C.H., and Conkling, M.A. 1995. Turning the tide against nematodes. The World and I, May 1995. pp. 184-191.

Opperman, C.H. 1995. Book Review: Plant Parasitic Nematodes in Temperate Agriculture. Evans, K., Trudgill, D.L., and Webster, J.M., eds. Parasitology Today 11: 42.

Invited Lectures

December 2004, Centennery Jubilee, Association of Applied Biologists, Oxford, UK. Genetic regulation of sporulation in Pasteuria penetrans.

October 2004, Organization of Nematologists of Tropical America, Puerto Vallarta, Mexico. Genome analysis of Pasteuria penetrans.

September 2004. Philip Morris International, Neuchatel, Switzerland. The tobacco genome initiative.

September 2004. 1st International Conference on Solanacea Genomics. Invited speaker on The tobacco genome initiative: a platform for gene discovery.

April 2004. Keygene N.V., Wageningen, The Netherlands. The tobacco genome initiative: A platform for gene discovery.

December 2003, Presidential Jubilee Meeting of the British Society of Plant Pathology, Nottingham, UK. Comparative genomics of free-living and parasitic nematodes: A gut response.

November 2003, Mediterranean Society of Plant Pathology, Calabria, Italy. Genomic analysis of nematode-parasitic bacteria.

July 2003, XI International Congress of Molecular Plant-Microbe Interactions, St. Petersburg, Russia. Genomic approaches to host-parasite interactions.

March 2003, UK Department of Environmental and Rural Affairs conference on Potato Cyst Nematode. Genetic and genomic approaches to nematode parasitism and parasites.

February 2003, International Congress of Plant Pathology, Christchurch, New Zealand, Structural genomics of Pasteuria penetrans.

October 2002, Oxford University, UK, Department of Zoology. Nematode natural enemies: Susceptibility, innate immunity, and novel therapeutics.

March 2001, XXIII Brazilian Congress of Nematology, Molecular approaches to the management of plant-parasitic nematodes. Marilia City, Brazil.

December 2000, Linnaen Society of London AAB Meeting, Towards physical maps of plant-parasitic nematode genomes.

November 2000, University of Bristol, UK, Department of Biology. Are mechanisms of nematode parasitism universal?

November 2000, Imperial College, Silwood Park, UK, Department of Pure and Applied Biology. Are mechanisms of nematode parasitism universal?

June 2000, Model Legumes International Meeting, Norwich, UK. Genetic approaches to understanding nematode parasitism.

April 2000, Genetical Society of Great Britain. 'Parasites and Pathogens', Genetical Society Spring Meeting, University of Warwick. Genetics and genomics: Approaches to nematode parasitism.

April 2000, The Sainsbury Laboratory, Norwich, UK. Integration of genetic and genomic approaches to nematode parasitism.

December 1999, Linnaen Society of London AAB Meeting, Are mechanisms of parasitism universal?

July 1999, International Plant Protection Congress, Jerusalem, Israel. Symposium on Genetic and molecular basis for recognition and response in plant-parasite interactions. Genomic approaches to the study of plant-parasitic nematodes.

October 1998, Rothamsted Experiment Station, UK, The soybean cyst nematode: a genetic model for nematode parasitism.

April 1998, BARD Conference, Jerusalem, Israel. New Approaches to Managing Soilborne Pathogens. Molecular genetics of nematode parasitism.

July, 1996, Third International Congress of Nematology, Symposium on Gentically Engineered Host Resistance, Guadaloupe. Bioengineering plant resistance to nematodes.

June, 1995, Canadian Phytopathological Society, Symposium on "Novel Methods of Disease Control", Bioengineering plant resistance to nematodes.

National/local

August 2004, Dept. of Plant Pathology, NCSU. The tobacco genome initiative: a platform for gene discovery.

August 2004. 43rd meeting, Society of Nematologists, Estes Park, CO. The Pasteuria penetrans genome: similarities and suprises. Symposium on Biological control of nemtodes.

August 2004. 43rd meeting, Society of Nematologists, Estes Park, CO. Control of sporulation in Pasteuria penetrans by metalloregulation. Symposium on Nematode-Bacteria Interactions.

August 2004. 43rd meeting, Society of Nematologists, Estes Park, CO. The whole genome sequence of Meloidogyne hapla: a community resource. Workshop on nematode genomes and genomics.

June 2003, 2nd International Symposium on Tobacco Research. Richmond, VA. The Tobacco Genome Initiative: an update.

April 2003, University of Nebraska spring Biotechnology speaker. Genomic approaches to host-parasite interactions.

June 2002, 1st International Congress of Legume Genetics and Genomics, Minneapolis, Mn. The Medicago truncatula-plant-parasitic nematode interaction: Susceptibility, shared signal transduction pathways, and host resistance.

June 2002, 1st Annual Tobacco Genomics Symposium, Virginia Crossings, Va. The status of the Tobacco Genome Intitiative.

April 2002, USDA-Beltsville, Genetic and genomic approaches to the study of plant-nematode parasitism.

April 2002, University of Ohio-Athens. Genetic and genomic approaches to the study of plant-nematode parasitism.

January 2002. Philip Morris USA, Richmond, Va. A strategy to sequence the tobacco genome.

September 2001, NC State University, Department of Plant Pathology. New approaches to developing novel nematode management strategies.

September 2001, Syngenta Agricultural Biotechnology Institute. Genomic analysis of the nematode-parasitic bacterium, Pasteuria penetrans.

August 2001, Joint American Phytopathology Society-Society of Nematologists-Mycological Society of America Meeting, Genetic and genomic approaches to the study of plant-nematode parasitism. Salt Lake City, UT

July 2001, 10th International Congress on Molecular Plant-Microbe Interactions, Mechanisms Of nematode parasitism: A functional approach, Madison, WI

April 2001, Oak Ridge National Laboratories Workshop on Genomics, Functional genomic analysis of multicellular parasites. Durham, NC

March 2001, Agricultural Awareness Forum, Facts and innuendos about the use of Genetically Modified Organisms in agriculture. NCSU.

January 2001, Keystone Symposium on Molecular Heminthology: An Integrated Approach, Genetic and genomic approaches to the study of plant-nematode parasitism. Taos NM

January 2001, Keystone Symposium on Molecular Heminthology: An Integrated Approach, Plant nematode genomes: maps, markers, and maybe synteny! Taos NM

November 2000, National Science Foundation, The biology of nematode parasitism.

September 2000, N.C. State University, Department of Zoology. Are mechanisms of nematode parasitism universal?

September 2000, Woods Hole Molecular Biology of Parasites Meeting. Genetic approaches to understanding nematode parasitism.

April 2000, Potomac Division, American Phytopathological Society. University of Delaware-Dover. Genetic approaches to understanding nematode parasitism.

September 1999, University of Missouri-Columbia, Department of Plant Pathology, Integration of genetic and genomic approaches to nematode parasitism.

July 1999, Exelixis Pharmaceuticals, South San Francisco, CA. Integration of genetic and genomic approaches to nematode parasitism.

July 1999, Joint American Society of Parasitology/Society of Nematology Meeting, Monterey, CA, Symposium on Nematode Genomics, Integration of genetic and genomic approaches to nematode parasitism.

June 1999, 12th International C. elegans Meeting, Madison, WI, Workshop on Parasitic Nematodes, Genetics of nematode parasitism.

February 1999. Texas A&M University, College Station, TX., Genetic approaches to nematode parasitism.

January 1999. Akkadix Corp., San Diego, CA., Genetic approaches to nematode parasitism.

January 1999. Mycogen Corp., San Diego, CA., Genetic approaches to nematode parasitism.

January 1999, US National Soybean Production Meeting, Orlando, FL, Soybean cyst nematode parasitism and genetics.

August 1998, Imperial College, London, Department of Biochemistry, Genetics of nematode parasitism.

August 1998, The Sanger Centre, Wellcome Trust Genomics Campus, Hinxton, UK. Genetics of nematode parasitism.

August 1998, International Nematology Symposium, Dundee, UK, Genomic approaches to the study of nematode parasites.

August 1998, International Congress of Plant Pathology, Edinburgh, UK, Symposium on Plant - Nematode Interactions, Molecular genetics of nematode parasitism.

September 1998, Eighth International Gatlinburg Symposium, Knoxville, TN., Symposium on Molecular Biology of the Soybean, The genetics of Heterodera glycines.

June 1998, East Coast C. elegans Meeting, Boston, MA, An unusual acetylcholinesterase identified in the nematode Meloidogyne incognita.

June 1998, East Coast C. elegans Meeting, Boston, MA, Genetic analysis of parasitism in the nematode Heterodera glycines.

June 1998, East Coast C. elegans Meeting, Boston, MA, Class II transposable elements in soybean cyst nematode.

May, 1998, Novartis AG, North Carolina, Invertebrate Genomics Group, Genetic and genomic strategies to understand nematode parasitism

March 1998, International Congress on Acetylcholinesterases, San Diego, CA. Symposium on Agricultural Importance of Acetylcholinesterases, Plant-parasitic nematode acetylcholinesterases.

November 1997, NemaPharm, Inc. Genome analysis of the soybean cyst nematode.

November 1997, Boston University, Department of Biology. Genome analysis of the soybean cyst nematode.

October 1997, University of Arizona - Tucson, Biotechnology Program. Genome analysis of the soybean cyst nematode.

October 1997, St. Louis University, Department of Biology. Genome analysis of the soybean cyst nematode.

April, 1997, Soybean Cyst Nematode Focus Group Meeting, St. Louis, MO. Genetic and molecular studies of nematode parasitism.

April, 1997, University of Missouri - Columbia. Genetic and molecular studies of nematode parasitism.

April, 1997, Monsanto Co. Genetic and molecular studies of nematode parasitism.

April, 1997, Washington University Medical School, Department of Genetics. Genetic and molecular studies of nematode parasitism.

September, 1996, N.C. State University, Department of Entomology. Deployment of transgenic resistance to plant-parasitic nematodes.

September, 1996, Monsanto Co. Plant responses to nematode feeding site establishment.

July, 1996, Eighth International Symposium on Molecular Plant-Microbe Interactions, Bioengineering Plant Resistance to Nematodes

April, 1996, Purdue University Plant Genetics Program, Bioengineering plant resistance to nematodes

April, 1996, St. Louis University, Department of Biology, Bioengineering plant resistance to nematodes

April, 1996, University of Minnesota, Plant Molecular Biology Institute, Spring Biotechnology Series, Bioengineering plant resistance to nematodes

February, 1996, Keystone Conference, Molecular Helminthology: An Integrated Approach, Bioengineering plant resistance to nematodes

October, 1995, Michigan State University, Lansing, MI, Bioengineering plant resistance to nematodes.

October, 1995, N.C. State University, Department of Crop Science, Bioengineering plant resistance to nematodes.

September, 1995, Washington State University, Prosser WA, Bioengineering plant resistance to nematodes.

September, 1995, University of Missouri-Columbia, Interdisciplinary Plant Genetics Program, Bioengineering plant resistance to nematodes.

August, 1995, Society of Nematologists, Symposium on "New Trends in Nematode Management", Bioengineering plant resistance to nematodes.

April, 1995 University of California-Riverside, Department of Nematology, Bioengineering plant resistance to nematodes.

April, 1995, N.C. State University, Department of Genetics, Genetics of soybean cyst nematode

April, 1995, N.C. State University, Department of Biochemistry, Plant parasitic nematode neurobiology and behavior.

March, 1995, Iowa State University Conference on Soybean Cyst Nematode, Ames, IA, Genetics of soybean cyst nematode.

March, 1995, University of Nebraska, Spring Speaker for Multidisciplinary Biotechnology Program, Bioengineering plant resistance to nematodes.

February, 1995, Soybean Breeder's Conference, St. Louis, MO, Symposium on "Development of Nematode Resistant Cultivars", Genetics of soybean cyst nematode

Research Funding History

USDA CSREES NRI Microbial Genome Sequencing Initiative. The complete genome sequence of Meloidogyne hapla (root-knot nematode) as the reference Tylenchid. 9/2004-8/2006. $1,590,000.

Syngenta, Functional genomics of the nematode-parasitic bacterium, Pasteuria penetrans. 7/2003-6/2005. $50,000.

Philip Morris USA. The Tobacco Genome Initiative. 7/1/02-12/31/06. $17,600,000.

Philip Morris USA. An approach to identify virtually all genomic sequences encoding genes from Nicotiana. 5/1/01-4/30/02. $1,095,000.

United Soybean Board. Parasitism genes in the soybean cyst nematode: biology and function. 10/1/00- 9/30/02. $308,000.

National Science Foundation Plant Genome Initiative. Genomic dissection of a nematode-plant interaction: a tool to study plant biology. 9/1/00-8/31/03. $2,607,829. (Bird, D.M., Clifton, S.W., Kieber, J.J., and Thorne, J.L., co-Pis).

Lawes Agricultural Trust. Genomic analysis of potato cyst nematode. 6/1/99-5/31/03. $146,700.

United Soybean Board. Genetic and molecular characterization of the soybean cyst nematode parasitic life cycle. 10/1/97-6/30/01. $975,000.

United Soybean Board. Direct assays for parasitism genes in resistance-breaking field populations of soybean cyst nematode. 10/1/97-4/30/00. $130,000.

N.C. Tobacco Foundation. Genetic diversity of the tobacco cyst nematode. 6/97-6/98. $10,500.

Mycogen Corp. In vitro feeding bioassays in plant-parasitic nematodes. 9/1/96-8/31/97. $39,000.

USDA-OICD. Analysis of genetic diversity among Radopholus spp. 8/1/96-7/31/98. $48,000.

North Carolina Biotechnology Center. Development of a plant parasitic nematode transformation system. 8/1/96-2/28/98. $40,000.

USDA Specific Cooperative Agreement. Transgenic nematode-resistant tomato. 8/95 - 8/97. $75,000. (Conkling, M.A., co-Pi)

Texas Cotton Growers Council. Transgenic nematode-resistant cotton. 1/96 - 12/96. $35,000. (Conkling, M.A., co-Pi)

North Carolina Biotechnology Center. Analysis of arrested development in plant-parasitic nematodes. 8/1/95 - 3/1/97. $40,000.

USDA National Research Initiative. Development of root-knot nematode resistant transgenic crops. 8/1/95 - 7/31/98. $225,000. (Conkling, M.A., co-Pi)

North Carolina Soybean Producers Association. Molecular identification of races of soybean cyst nematode. 5/1/95 - 4/30/97. $23,000.

USDA National Research Initiative. Genetic analysis of Heterodera glycines parasitism of soybean. 9/1/94 - 8/31/96. $120,000.

North Carolina Soybean Producers Association. Molecular identification of races of soybean cyst nematode. 5/1/93 - 4/30/95. $18,000.

Monsanto Company. Nematode-Specific Cartridges for the Production of Transgenic Cultivars with Broad Resistance to Plant-Parasitic Nematodes. 8/1/92 - 7/31/95. $321,160. (Conkling, M.A., co-Pi)

USDA National Research Initiative. Characterization of a Nematode-Responsive Plant Gene Promoter. 9/15/92 - 9/14/95. $225,000. (Conkling, M.A., co-Pi)

Multidisciplinary and Training Support Grants

National Science Foundation IGERT on Training in Genomics. 10/00-9/04. $2,600,000. (14 faculty investigators).

North Carolina Biotechnology Center Institutional Development Grant. Instrumentation and software supplement for the Genome Research Laboratory. 6/00-5/01. $31,500.

USDA National Needs Graduate Fellowship Program. Molecular Crop Protection. 9/93 - 8/98. $108,000. (Daub, M.E., co-PI)

NSF-USDA-DOE Plant Biology Training Grant. Interdisciplinary Research Training Group in the Biology of Transgenic Plants. 9/94 - 8/99, $1,336,000 (Thompson, W.F., Weissinger, A., Spiker, S., Chilton, M-D., and Boston, R., co-Directors).

North Carolina Biotechnology Center Event Support Grant. Molecular Technology for Plant Improvement 1996 Meeting. $1,500.00.

North Carolina Biotechnology Center Event Support Grant. Molecular Technology for Plant Improvement 1997 Meeting. $1,500.00

College/University Initiatives

North Carolina State University. College Of Agriculture and Life Sciences Genome Research Laboratory. 6/98 - present, $2,500,000 (Lommel, S.A., and Tompson, W.F., co-PI).

Professional Affiliations

American Association for the Advancement of Science
American Phytopathological Society
European Society of Nematologists
International Society of Plant-Microbe Interactions
Society of Nematologists

Awards and Honors

January, 2001 Researcher-in-Residence, The Santa Fe Institute, Santa Fe NM

1998 - present Lawes Trust Senior Fellowship, Rothamsted Research Ltd., Biotechnology and Biological Sciences Research Council, United Kingdom

1983 - 1985 R.J. Reynolds Graduate Fellowship, Department of Entomology and Nematology, University of Florida

Professional Service on Campus
Professional Committees

Society of Nematologists Plant Resistance to Nematodes Committee (2000-present)

American Phytopathogical Society Steering Committee, Microbial Genome Sequencing (2002-present)

NCR-172 Committee, Molecular genetics of sedentary endoparasitic nematodes. Founding member (1991-1998. Chair, 1994).

S-235 Committee, Sustained nematode management in cropping systems. Collaborator (1992-present).

Organizer, New Trends in Nematode Management Symposium, 1995 Annual Society of Nematologists Meeting, Little Rock, AR.

Local Arrangements Committee, Society of Nematologists Annual Meeting, 1988. Raleigh, NC.

Organizer, NCSU Biotechnology Faculty Retreat, 1992, 1995, 1996.

Organizer, NCSU Molecular Technology for Plant Improvement symposium, 1996, 1997.

Society of Nematologists representative to the International Federation of Societies of Parasitology, 1997 - 2000.

Society of Nematologists liason, Proposed EPA Plant Pesticide Rule, 1997 - 1999.

Science Advisory Board, Cambria BioSciences LLC, Boston, MA.

National Steering Committee, Microbial Genome Sequencing. American Phytopathogical Society

2001-present Contributing Editor, Faculty of 1000

1998-2002 Editor, Nematology

1996-1999 Associate Editor, Phytopathology 1990-1998 Associate Editor, Fundamental and Applied Nematology

1993-1995 Associate Editor, Journal of Nematology

1993-present Plant-Parasitic Nematode Genetic Nomenclature Oversight Committee

Consultant, BASF/BPS, Research Triangle Park, NC 2001-2003

2004 USDA-CSREES NRI panel member, Arthropods and Nematodes: Gateways to Genomics

2004 NIH Special Programs panel, SBIR for Biomedicine

2001-present Contributing Editor, Faculty of 1000

1993-present Plant-Parasitic Nematode Genetic Nomenclature Oversight Committee

National Steering Committee, Microbial Genome Sequencing. American Phytopathogical Society

 
 
 
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Charles H. Opperman, Director
David McK. Bird, Director
Reenah Schaffer, Administrator


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Comprehensive Transcriptome Profiling in Tomato Reveals a Role for Glycosyltransferase in Mi-Mediated Nematode Resistance Plant Physiology 144:1079-1092 (2007)
Jennifer E. Schaff, Dahlia M. Nielsen, Chris P. Smith, Elizabeth H. Scholl and David McK. Bird

Phylogenetic Analysis of Pasteuria penetrans by Use of Multiple Genetic Loci Journal of Bacteriology, August 2005, p. 5700-5708, Vol. 187, No. 16
Lauren Charles, Ignazio Carbone, Keith G. Davies, David Bird, Mark Burke, Brian R. Kerry, and Charles H. Opperman

Root-knot nematodes and bacterial Nod factors elicit common signal transduction events in Lotus japonicus PNAS | February 22, 2005 | vol. 102 | no. 8 | 3147-3152
Ravisha R. Weerasinghe, David McK. Bird and Nina S. Allen

Virulence Genes in Heterodera glycines: Allele Frequencies and Ror Gene Groups Among Field Isolates and Inbred Lines (pdf file)
Phytopathology | February 2005 | Volume 95, Number 2
K. Dong, K. R. Barker, and C. H. Opperman. Pages 186-191.

Lotus japonicus: A New Model to Study Root-Parasitic Nematodes
Dasharath Prasad Lohar and David McK. Bird
Plant and Cell Physiology, 2003, Vol. 44, No. 11 1176-1184

Horizontally transferred genes in plant-parasitic nematodes: a high-throughput genomic approach
Elizabeth H Scholl, Jeffrey L Thorne, James P McCarter, and David Mck Bird
Genome Biology 2003, Vol. 4, Issue 6

Cytokinins play opposite roles in lateral root formation, and nematode and Rhizobial symbioses
Lohar, Dasharath Prasad, Schaff, Jennifer E., Laskey, James G., Kieber, Joseph J., Bilyeu, Kristin D., Bird, David McK.
The Plant Journal 38 (2), 203-214. (2004)

Model systems in agriculture: Lessons from worms.
Bird, David McK.
Annals of Applied Biology 146 (2), 147-154. (2005)

Resolving tylenchid evolutionary relationships through multiple gene analysis derived from EST data
Elizabeth H. Scholl and David McK. Bird
In Press, Corrected Proof, Available online 3 May 2005

Plant Parasitic Nematodes: Habitats, Hormones, and Horizontally-Acquired Genes
David McKenzie Bird, Hinanit Koltai
Journal of Plant Growth Regulation, Volume 19, Issue 2, Jun 2000, Pages 183 - 194

Alkahest NuclearBLAST : a user-friendly BLAST management and analysis system
Diener SE, Houfek TD, Kalat SE, Windham DE, Burke M, Opperman C, Dean RA
BMC Bioinformatics 2005, 6:147 (15 June 2005)

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Wormbase
Nematode.Net
DNA Analysis
Entrez
Blaxter Lab
C. Elegans WWW server
Agriculture Network Information Center
Genome Research Laboratory


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The Center for the Biology of Nematode Parasitism is located on NCSU's Centennial Campus


North Carolina State University's Centennial Campus is a research and advanced technology community where university, industry and government partners interact in multidisciplinary programs directed toward the solution of contemporary problems.

In this "knowledge enterprise zone," clusters of activity break down traditional, artificial barriers to create, integrate, and apply advancements in knowledge. The resulting synergy leads to:

  • technological innovation and transfer;
  • real-world teaching and learning;
  • sound business investment; and,
  • greater quality of life for North Carolina and beyond.


  • The unique master plan for this environmentally sensitive, mixed-use, academic village responds to the professional, educational and recreational needs of the University's faculty, staff and student body, as well as those of corporate and government affiliates whose presence on Centennial Campus adds to its vigor and effectiveness.

    Centennial Campus is providing a new dimension of excellence for the 21st century in the performance of North Carolina State University's land-grant mission of teaching, research and service to the people of North Carolina.

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